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We are recruiting for a new trial in Melbourne, Australia

It is well known that our diet influences the risk of high blood pressure. Recently it’s been thought that diet may do this by affecting intestinal permeability (also called “leaky gut”). We want to see if intestinal permeability is present in high blood pressure. To do this, we are looking for volunteers with normal and high blood pressure, including those on medication, to have the leakiness of their guts tested.
 

We are recruiting:

  • People with normal blood pressure

  • People with high blood pressure, not on medication

  • People with high blood pressure, on medication (including those with resistant hypertension)

 

The purpose of this research is to determine if intestinal permeability is different with high blood pressure. This could lead to new gut-targeted strategies to target high blood pressure.

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Please register your interest using this link and we will get back to you as soon as possible.

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Please see the inclusion and exclusion criteria below.

HYPER Volunteer Recruitment Flyer BP_97737_v1.png

To be eligible to be part of this study you need to be:

 

You cannot participate in the study if you:

  • Have blood pressure ≥165/100 mmHg – if your blood pressure is this high we suggest you see your GP to start antihypertensive therapy soon.

  • Have used antibiotics or probiotics in the past 3 (in this case you may be eligible to participate at a later stage, so get in touch with us)

  • Are pregnant or breastfeeding.

  • Have gastrointestinal diseases (including inflammatory bowel disease, lactose intolerance, celiac disease, chronic pancreatitis or other malabsorption disorder).

  • Have ever had gastrointestinal surgery.

  • Are taking stimulant medication (e.g. to treat ADHD)

  • Have chronic kidney disease (with an eGFR of less than 45)

  • Have Alzheimer’s disease or dementia.

 

This study involves two visits to the Victorian Heart Hospital in Clayton, as well as dropping off samples after the second visit:

  • Visit 1 will take 60-90 minutes, and you will be shown how to use a machine to measure your blood pressure for the next 24 hours.

  • Visit 2 will take approx. 5 hours, and we will measure how leaky your gut is. We will also give you some delicious blue muffins, for testing your gastrointestinal transit time (how quick things go from your mouth to the other end). The next day, you will need to drop-off a urine collection.

 

For further information, please contact: hyper@monash.edu or call 0466 126 918.

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Study Coordinator:

Dr Matthew Snelson

National Heart Foundation Postdoctoral Fellow

Hypertension Research Laboratory

School of Biological Sciences

Monash University

Phone: +61 3 9905 0437 | Email: matthew.snelson@monash.edu |

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